Diverse cytokines can signal through receptor complexes containing the gp130 subunit. These cytokines, which include interleukin (IL)-6, IL-11, leukemia inhibitory factor (LIF), oncostatin M (OSM), ciliary neurotrophic factor (CNTF), cardiotrophin-1 (CT-1), and CLC (cardiotrophin-like cytokine), are implicated in inflammatory and immune responses, heart development, and fertility.

2015-06-01 · Several soluble forms of gp130 occur naturally in the human blood, which are generated by differential mRNA splicing and alternative polyadenylation . These sgp130 variants contain different numbers of the six extracellular domains of gp130 and differ in their efficiency to inhibit IL-6 trans-signaling as well as their biological half-life.

Protein names i: Submitted name: Gp130 Imported. Gene names i: Name:gp130 2017-02-24 2021-03-26 Rabbit polyclonal CD130 (gp130) antibody. Validated in WB, IHC, Flow Cyt and tested in Mouse, Human. Cited in 6 publication(s). Immunogen corresponding to synthetic peptide. CD130, CD130 antigen, CDw130, gp130, gp130 of the rheumatoid arthritis antigenic peptide-bearing soluble form, oncostatin M receptor, IL-6 receptor subunit beta, IL-6R subunit beta, interleukin receptor beta chain, Interleukin-6 receptor subunit beta, Interleukin-6 signal transducer, Membrane glycoprotein 130, membrane glycoprotein gp130, Oncostatin-M receptor subunit alpha Since IL-6 employs the cytokine receptor gp130 to primarily activate the STAT3 pathway, here we evaluate whether gp130-dependent STAT3 activation modulates atherosclerosis. METHODS: High-fat diet-induced atherosclerosis was established in ApoE(-/-) mice crossed with gp130(F/F) knock-in mice displaying elevated gp130-dependent STAT3 activation and production of the APR protein, serum … 2003-06-27 We further show that two gp130-signaling cytokines, IL-6 and IL-27, impair the suppressive capacity of human Treg cells.

Gp130

The binding of a ligand to its receptor induces the dimerization of GP130, leading to activation of the Jak tyrosine kinase and to tyrosine phosphorylation of GP130. Gp130, the common signal transducing receptor component shared by the functional receptor complexes of the IL-6 family of cytokines, belongs to the classI cytokine receptor family. Binding of IL-6 or IL-11 to either the membrane-anchored or soluble IL-6 R or IL-11 R, respectively, initiates the association of IL-6 R (IL-11 R) with gp130. Glycoprotein 130 kDa (gp130) is a trans-membrane protein, which is ubiquitously expressed. It serves as the signal transduction unit of a family of cytokines: the IL-6 family. gp130 (glycoprotein 130), a coreceptor of oncostatin M, is essential for cardiomyocyte proliferation and heart regeneration.

Members of this family have been shown to enhance the survival of migratory (E10.5) or postmigratory (E12.5) murine primordial germ cells (PGCs) in culture; however, it is uncertain what role these cytokines play during PGC development in vivo. 16193 Ensembl ENSG00000136244 ENSMUSG00000025746 UniProt P05231 P08505 RefSeq (mRNA) NM_000600 NM_001318095 NM_001371096 NM_031168 NM_001314054 RefSeq (protein) NP_000591 NP_001305024 NP_001358025 NP_001300983 NP_112445 Location (UCSC) Chr 7: 22.73 – 22.73 Mb Chr 5: 30.01 – 30.02 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Interleukin 6 (IL-6) is an interleukin that acts as Gp130 engagement leads to activation of Src and JAK/Tyk tyrosine kinases, as well as the STAT family of transcription factors (4, 5). IL-6 is the prototypic gp130-cytokine and binds the gp130 receptor through three conserved epitopes (sites I, II, and III), of which site III is unique to gp130-cytokines (6–9).

3 gp130 in TNF-a expression sgp130 concentrations in the culture supernatants of PMN Soluble gp130 is the natural inhibitor of soluble interleukin-6 receptor

Blockering av IL-6 / GP130-signalering med MR16-1 förbättrad MCD-dietinducerad hepatisk steatos, men Uppsats: Correlations between unexplained infertility and single nucleotide polymorphism in the genes of leukemia inhibitory factor receptor and gp130. Gleason-Pfauter GP130 · Prisinfo Ring. Düsseldorf Tyskland.

Here, we investigate the cellular localization, regulation, and possible function of two IL-6 receptors (IL-6Ralpha and gp130) in mouse and human fallopian

frakt Cytokinreceptor gp130 (Cytokine Receptor gp130). Ord. Cytokinreceptor gp130. Förklaring. 1.

GP130 signaling is required for tumor cell survival in diverse forms of ALK- anaplastic large cell lymphoma, even in the presence of JAK1/STAT3 mutations. GP130 is the shared receptor for members of the IL6 family of cytokines. Members of this family have been shown to enhance the survival of migratory (E10.5) or postmigratory (E12.5) murine primordial germ cells (PGCs) in culture; however, it is uncertain what role these cytokines play during PGC development in vivo. 16193 Ensembl ENSG00000136244 ENSMUSG00000025746 UniProt P05231 P08505 RefSeq (mRNA) NM_000600 NM_001318095 NM_001371096 NM_031168 NM_001314054 RefSeq (protein) NP_000591 NP_001305024 NP_001358025 NP_001300983 NP_112445 Location (UCSC) Chr 7: 22.73 – 22.73 Mb Chr 5: 30.01 – 30.02 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Interleukin 6 (IL-6) is an interleukin that acts as Gp130 engagement leads to activation of Src and JAK/Tyk tyrosine kinases, as well as the STAT family of transcription factors (4, 5).
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280,40 kr. LRC · 4 Juni 2012 · #5,308. Tja, eftersom den förra bilden gick så snabbt kan jag ta en till, som nog är lite svårare: gp130.jpg Father: Claes Erik Andersson Born: 1848, Sweden Marr: 1876 Died: 1912.

Artikelnummer: GP130. Slut i lager.
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Munters installed GP130 air heaters, equipped with oil burners were installed to keep the greenhouse temperature under control during the cold season to avoid

Kaposi's sarcoma–associated herpesvirus encodes a functional homolog of human interleukin-6 (IL-6) that activates human gp130. In the 2.4 angstrom crystal structure of the extracellular signaling Search results for gp130 at Sigma-Aldrich.

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GP130 is a signal-transducing subunit shared by the receptors for the IL-6 family of cytokines (1-3). The binding of a ligand to its receptor induces the dimerization of GP130, leading to activation of the Jak tyrosine kinase and to tyrosine phosphorylation of GP130.

METHODS: High-fat diet-induced atherosclerosis was established in ApoE(-/-) mice crossed with gp130(F/F) knock-in mice displaying elevated gp130-dependent STAT3 activation and production of the APR protein, serum … 2003-06-27 We further show that two gp130-signaling cytokines, IL-6 and IL-27, impair the suppressive capacity of human Treg cells. Finally, we show that gp130 signaling reduces the expression of the transcription factor Helios, whose expression is essential for stable Treg function. View R&D Systems research products for gp130. 0.1 - 8 ng/mL (Cell Culture Supernates), 0.3 - 16 ng/mL (Serum, EDTA Plasma, Heparin Plasma, Citrate Plasma) ab217671 Anti-CD130 (gp130) antibody [EPR21732] was shown to specifically react with CD130 (gp130) in wild-type A549 cells. Loss of signal was observed when knockout cell line ab266938 (knockout cell lysate ab257207) was used. 2019-08-08 THE JOURNAL † RESEARCH † www.fasebj.org Myeloid cells require gp130 signaling for protective anti-inflammatory functions during sepsis Sara Dutton Sackett,*,†,1 Tobias Otto,*,1 Antje Mohs,* Leif E. Sander,*,‡,§ Sonja Strauch,* Konrad L. Streetz,* Daniela C. Kroy,* and Christian Trautwein*,2 *Department of Internal Medicine III, University Hospital Rheinisch-Westfalische Technische Cardiomyocyte-specific deletion of Yap in Myh6-gp130 ACT mice blocked the effect of gp130 activation–induced heart regeneration in juvenile mice.