Lund January 9, 2017 - Active Biotech AB announces today that the European Patent Office has decided to grant Active Biotech's patent application covering tasquinimod for use in | March 30, 2021

Tasquinimod är under utveckling för behandling av multipelt myelom, en ovanlig form av potent anti-tumor activity in pre-clinical models of multiple myeloma.

Myeloma (also called multiple myeloma) is a cancer that forms in white blood cells. It typically affects the bones as the cancerous cells accumulate in a person's bone marrow. The signs and symptoms of myeloma vary with each person and stag Multiple myeloma is a type of blood cancer. The American Society of Clinical Oncology notes that it's relatively uncommon in the United States, affecting about one in every 132 people. Around 30,000 new cases are diagnosed each year.

Tasquinimod myeloma

In a clinical study, SARCLISA given with Pomalyst® (pomalidomide) and dexamethasone (Pd) extended the time people lived without their multiple myeloma getting worse compared to Pd alone (median of 11.5 months vs 6.5 months). Tasquinimod – en potentiell ny produktklass för behandling av multipelt myelom Den kliniska fas Ib/IIa-studien i återkommande refraktärt multipelt myelom pågår vid Abramson Cancer Center i Philadelphia, USA. Studien utvärderar två behandlingsregimer: tasquinimod som monoterapi For both single agent tasquinimod and the combination of tasquinimod and IRd, exploratory expansion cohorts will be enrolled to characterize the anti-myeloma activity of each regimen. Active Biotech announces first patient dosed in phase 1b/2a study of tasquinimod use in treatment of multiple myeloma, by @nasdaq Tasquinimod har patentskydd för behandling av multipelt myelom till 2035. Utvecklingen av tasquinimod har tidigare inriktats mot behandling av prostatacancer där klinisk effekt och god Tasquinimod has been studied in both healthy subjects and cancer patients. Clinical effects and an overall good tolerability have been demonstrated in 1500 patients, representing more than 650 patient-years of exposure to tasquinimod. Today, tasquinimod is in development for treatment of multiple myeloma, a rare form of blood cancer with a high Tasquinimod (TASQ) is an investigational drug that targets MDSCs via the S100A9 protein. In pre-clinical models of MM, TASQ has significant anti-tumor effects as a single agent and in combination with bortezomib, a proteasome inhibitor (PI) and lenalidomide, an immunomodulator (IMiD) (Lin C, et al.

Avslutad.

För både tasquinimod som monoterapi och kombinationen av med givna responskriterier från International Myeloma Working Group. Studien

Tasquinimod utvecklas som en ny immunmodulerande behandling för multipelt myelom. Tasquinimod har tidigare studerats som ett anticancermedel hos patienter med solida cancertumörer, inklusive en randomiserad fas 3-studie på patienter med metastaserande prostatacancer. Tasquinimods tolerabilitet är väl studerad i dessa tidigare studier.

Multiple myeloma (MM) is an incurable hematological malignancy characterized by clonal proliferation of plasma cells localized preferentially in

Phase 2 and 3 studies.

Studiens primära mål är att fastställa optimal dos och behandlingsschema för tasquinimod som monoterapi och i kombination med IRd. Tasquinimod acts on immunosuppressive cells that play a key role in tumor progression in multiple myeloma due to their capability to promote immune-escape, angiogenesis, and metastasis.
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Early Relapse Multiple Myeloma The following is a listing of clinical trials for patients with multiple myeloma who have received one to two prior lines of therapy . Phase 1 Study of Tasquinimod Alone and in Combination With Standard Therapy for Relapsed or Refractory Myeloma

feb 2021 Tasquinimod, is in clinical phase Ib/IIa for treatment of multiple myeloma. Laquinimod is advancing to phase II for treatment of non-infectious However, in certain cancers, such as melanoma, multiple myeloma, and prostate Tasquinimod modulates suppressive myeloid cells and enhances cancer 26 feb 2021 Tasquinimod, is in clinical phase Ib/IIa for treatment of multiple myeloma. Laquinimod is advancing to phase II for treatment of non-infectious Tasquinimod, an immunomodulator, will enter a Phase Ib/IIa trial on multiple myeloma in partnership with the University of Pennsylvania Medical School. 5 Jan 2021 Tasquinimod, is in clinical phase Ib/IIa for treatment of multiple myeloma.
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In August, the first patient was dosed in the phase 1b/2a clinical study of tasquinimod for treatment of relapsed or refractory multiple myeloma. The study, which

Lund Sweden, August 3, 2020 - Active Biotech (NASDAQ STOCKHOLM: ACTI) today announces that the first patient has been dosed in the phase 1b/2a clinical study of Tasquinimod (ABR-215050, Active Biotech, Lund, Sweden) is an investigational drug that binds the S100A9 protein and inhibits the interactions with its receptors. Tasquinimod utvecklas som en ny immunmodulerande behandling för multipelt myelom. Tasquinimod har tidigare studerats som ett anticancermedel hos patienter med solida cancertumörer, inklusive en randomiserad fas 3-studie på patienter med metastaserande prostatacancer.

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Tasquinimod – en potentiell ny produktklass för behandling av multipelt myelom Den kliniska fas Ib/IIa-studien i återkommande refraktärt multipelt myelom pågår vid Abramson Cancer Center i Philadelphia, USA. Studien utvärderar två behandlingsregimer: tasquinimod som monoterapi

5 Jan 2021 Tasquinimod, is in clinical phase Ib/IIa for treatment of multiple myeloma. Laquinimod is advancing to phase II for treatment of non-infectious 2017年4月18日 Active Biotech公司近日宣布，美国食品和药物管理局（FDA）已授予实验性抗癌药 tasquinimod治疗多发性骨髓瘤（multiple myeloma，MM）的 3 aug 2020 För både tasquinimod som monoterapi och kombinationen av med givna responskriterier från International Myeloma Working Group.